Dr. Shamir Mehta is the Douglas A. Holder/PHRI Endowed Chair in Interventional Cardiology and a Professor of Medicine at McMaster University. He is an interventional cardiologist at Hamilton Health Sciences and Senior Scientist at the Population Health Research Institute in Hamilton, Canada. He graduated from the University of Toronto’s Faculty of Medicine where he also completed internal medicine and cardiology training, followed by an interventional cardiology fellowship at the University Health Network.  He completed a research fellowship and Master’s in Health Research Methodology at McMaster University supported by a Canadian Institutes of Health Research New Investigator Award.  In 2004 he was named one of Canada’s Top 40 Under 40.  In 2022, he received the Canadian Cardiovascular Society’s highest honor for research achievement, the CCS Research Achievement Award.

Dr. Mehta has published hundreds of articles and holds peer-review operating grants from the CIHR and the Heart and Stroke Foundation of Canada, as well as grants from Industry.  He has led large-scale trials evaluating antiplatelet and antithrombotic therapies in patients with acute coronary syndromes and landmark trials evaluating pragmatic interventions in ACS including TIMACS, evaluating optimal timing of invasive intervention in patients with ACS, RIVAL, establishing the benefit of a radial versus femoral artery approach in patients with ACS, and the recently published COMPELTE trial evaluating a strategy of complete revascularization in patients with STEMI and multivessel disease.  The COMPLETE trial was recognized by the editors of the New England Journal of Medicine as one of its Most Notable Articles of 2019. Dr. Mehta is currently the Principal Investigator of the COMPLETE-2 trial, a 5,100-patient multinational trial evaluating the role of physiology-guided versus angiography-guided isPCI strategies to treat non-culprit lesions in patients with ACS and multivessel coronary artery disease, including a large-scale study of optical coherence tomography intracoronary imaging to predict cardiovascular events in these patients.

Dr. Mehta has a busy interventional and structural cardiology practice and leads the percutaneous mitral and tricuspid valve programs at HHS. He is the Program Director of the Royal College-certified Interventional Cardiology Training Program at McMaster University and Hamilton Health Sciences, one of the largest training programs in interventional cardiology in the country.

Publications